See google scholar for the most up-to-date list
2024
Cizauskas HE, Burnham HV, Panni A, Pena A, Alvarez-Arce A, Davis MT, Araujo K, Delligatti C, Edassery S, Kirk JA, Arora R, Barefield DY. Proteolytic degradation of atrial sarcomere proteins underlies contractile defects in atrial fibrillation. American Journal of Physiology – Heart and Circulatory Physiology, 2024 (accepted)
Delligatti C, Kirk JA. Glycation in the Cardiomyocyte. Vitamins & Hormones, 2024 (in press)
Lindsey ML, Kirk JA, LeBlanc AJ, Brunt KR, Carter JR, Keehan KH, Ripplinger CM, Kleinbongard P, Kissiri Z. Looking Backward to Plan for Forward. American Journal of Physiology – Heart and Circulatory Physiology, 2024
Martin TG*, Sherer LA*, Kirk JA. BAG3 localizes to mitochondria in cardiac fibroblasts and regulates mitophagy. American Journal of Physiology – Heart and Circulatory Physiology, 2024 (in press), * equal contributions
Lindsey ML, Brunt KR, Kleinbongard P, Carter JR, Ripplinger CM, Kassiri Z, Keehan KH, LeBlanc AJ, Kirk JA. The Heart of Physiological Reports. Physiological Reports, 2024
2023
Barefield DY, Tonino P, Woulfe KC, Rahmanseresht S, O’Leary TS, Burnham H, Wasserstrom JA, Kirk JA, Previs MJ, Granzier HL, McNally EM. Myosin binding protein H-like regulates myosin binding protein distribution and function in atrial cardiomyocytes. PNAS, 2023 (accepted)
Martin TG*, Pak H*, Gerhard GS, Merali S, Merali C, Lemster B, Dubey P, McTiernan CF, Bristow MR, Feldman AM, Kirk JA. Dysregulated autophagy and sarcomere dysfunction in heart failure patients with co-occurrence of P63A and P380S BAG3 variants. Journal of the American Heart Association, 2023 (accepted), * co-first authors
Shen S, Shao S, Papadaki M, Kirk JA, Campbell SG. Evaluation of Porcine Psoas Major as a Scaffold Material for Engineered Heart Tissues. Tissue Eng Part C Methods, 2023
Kirk JA. Going Further with Half as Much: It’s in the BAG. JACC Basic to Translational Science, 2023
Ma W*, Lee KH*, Delligatti C*, Davis MT, Zheng Y, Gong H, Kirk JA, Craig R, Irving T. The structural and functional integrities of permeabilized porcine myocardium are mostly preserved by liquid nitrogen freezing. Journal of General Physiology, 2023, * co-first authors
Lindsey ML, Kassiri Z, LeBlanc AJ, Ripplinger CM, Kirk JA, Carter JR, Kleinbongard P, Brunt KR. Spring cleaning: Freshening up the portfolio. American Journal of Physiology – Heart and Circulatory Physiology, 2023
Wang J, Tomar D, Martin TG, Dubey S, Dubey PK, Song J, Landensberg G, McCormick MG, Myers VD, Merali S, Merali C, Lemster B, McTiernan CF, Kahlili K, Madesh M, Cheung JY, Kirk JA, Feldman AM. Bag3 regulates Mitochondrial Function and the Inflammasome Through Canonical and Non-Canonical Pathways in the Heart. JACC Basic to Translational Science, 2023. 10.1016/j.jacbts.2022.12.013
Lindsey ML, Kleinbongard P, Kassiri Z, Carter JR, Keehan KH, Ripplinger CM, LeBlanc AJ, Brunt KR, Kirk JA. We Asked and You Answered. American Journal of Physiology – Heart and Circulatory Physiology, 2023
Ijichi T, Sundararaman N, Martin TG, Pandey R, Koronyo E, Kirk JA, Marban E, Van Eyk JE, Ferb-Bober J. Peptidyl arginine deiminase inhibition alleviates angiotensin II-induced fibrosis. Am J of Transl Res, 2023, PMID: 37560217, PMCID: PMC10408542
2022
Lindsey ML, Carter JR, Ripplinger CM, Kassiri Z, Keehan KH, Brunt KR, Kirk JA, Kleinbongard P, LeBlanc AJ. Sex Still Matters in Cardiovascular Research. American Journal of Physiology – Heart and Circulatory Physiology, 2022. PMID: 36487186, PMCID: PMC9799132
Eaton DM*, Martin TG*, Kasa M, Djalinac N, Ljubojevic-Holzer S, Lewinksi D, Pottler M, Kampaengsri T, Krumphuber A, Scharer K, Maechler H, Zirlik A, McKinsey TA, Kirk JA, Houser SR, Rainer PP, Wallner M. HDAC inhibition regulates cardiac function by increasing myofilament calcium sensitivity and decreasing diastolic tension. Pharmaceutics, in press, 2022 *co-first authors
Stachowski-Doll MJ, Papadaki M, Martin TG, Ma W, Gong HM, Shao S, Shen S, Muntu NA, Kumar M, Perez E, Martin JL, Moravec CS, Sadayappan S, Campbell SG, Irving T, Kirk JA. GSK-3β Localizes to the Cardiac Z-Disc to Maintain Length Dependent Activation. Circulation Research, 2022, PMID: 35168370
2021
Lindsey ML, Brunt KR, Kirk JA, Kleinbongard P, Calvert JW, de Castro Bras LE, DeLeon-Pennell KY, Del Re DP, Frangogiannis NG, Frantz S, Gumina RJ, Halade GV, Jones SP, Ritchie RH, Spinale FG, Thorp EB, Ripplinger CM, Kassiri Z. Guidelines for in vivo mouse models of myocardial infarction. American Journal of Physiology – Heart and Circulatory Physiology, 2021.
Lindsey ML, LeBlanc AJ, Ripplinger CM, Carter JR, Kirk JA, Keehan KH, Brunt KR, Kleinbongard P, Kassiri Z. Reinforcing rigor and reproducibility expectations for use of sex and gender in cardiovascular research. American Journal of Physiology – Heart and Circulatory Physiology, 2021.
Papadaki M, Kampaengsri T, Barrick SK, Campbell SG, Lewinski D, Rainer PP, Harris SP, Greenberg MG, Kirk JA. Myofilament glycation in diabetes depresses contractility by inhibiting tropomyosin movement, is rescued by cMyBPC domains. Journal of Molecular and Cellular Cardiology, 2021. PMID: 34487755
Martin TG, Delligatti CE, Muntu NA, Stachowski-Doll MJ, Kirk JA. Pharmacological inhibition of BAG3-HSP70 with the proposed cancer therapeutic JG-98 is toxic for cardiomyocytes. Journal of Cellular Biochemistry, 2021. PMID: 34487557
Kirk JA, Cheung CY, Feldman AM. Therapeutic targeting of BAG3: Considering its complexity in cancer and heart disease. Journal of Clinical Investigation. 2021. PMID: 34396980
Zhang M, Flury S, Kim CK, Chung WCJ, Kirk JA, Pak TR. Absolute quantification of phosphorylated ERβ amino acids in the hippocampus of women and in a rat model of menopause. Endocrinology. 2021. PMID: 34147032
Lindsey ML, de Castro Bras LE, DeLeon-Pennell KY, Frangogiannis NG, Halade GV, O’Meara CC, Spinale FG, Kassiri Z, Kirk JA, Kleinbongard P, Ripplinger CM, Brunt KR. Reperfused vs. Non-reperfused Myocardial Infarction: when to use which model. American Journal of Physiology – Heart and Circulatory Physiology, 2021. PMID: 34114891
Martin TG, Tawfik S, Moravec CS, Pak TR, Kirk JA. Cardiac Bcl-2-associated athanogene-3 (BAG3) expression and myofilament localization are differentially affected by age, sex, and disease. American Journal of Physiology – Heart and Circulatory Physiology, 2021. PMID: 33989081
Martin TG, Meyers VD, Dubey P, Dubey S, Perez E, Moravec CS, Willis MS, Feldman AM, Kirk JA. Cardiomyocyte Contractile Impairment in Heart Failure Results from Reduced BAG3-mediated Sarcomeric Protein Turnover. Nature Communications, 12(1): 2942, 2021. PMID: 34011988
Guo S, Okyere AD, McEachern E, Strong JL, Carter RL, Patwa VC, Thomas TP, Landy M, Song J, Lucchese AM, Martin TG, Gao E, Rajan S, Kirk JA, Koch WJ, Cheung JY, Tilley DG. Epidermal growth factor receptor-dependent maintenance of cardiac contractility. Cardiovascular Research, 2021. PMID: 33892492
Lindsey ML, Kassiri Z, Keehan KH, Brunt KR, Carter JR, Kirk JA, Kleinbongard, LeBlanc AJ, Ripplinger CM. We are the Change We Seek. American Journal of Physiology Heart and Circulatory Physiology, 2021
2020
DiNello E, Bovo E, Thuo P, Martin TG, Kirk JA, Zima AV, Cao Q, Kuo IY. Deletion of cardiac polycystin 2/PC2 results in increased SR calcium release and blunted adrenergic reserve. American Journal of Physiology Heart and Circulatory Physiology, 2020. PMID: 32946258, PMCID: PMC7789970
Martin TG, Kirk JA. Under construction: the dynamic assembly and degradation of the cardiac sarcomere. Journal of Molecular and Cellular Cardiology, 2020. PMID 32920010
Kim C, Asimes AD, Zhang M, Son B, Kirk JA, Pak T. Differential stability of miR-9-5p and miR-9-3p in the brain is determined by their unique cis- and trans- acting elements. In press, eNeuro, 2020
Ai L, Perez E, Heroux M, Zlobin A, Asimes AD, Hiske MA, Chung CS, Pak TR, Kirk JA. Adolescent Binge Alcohol Exposure Impairs Normal Heart Growth. Journal of the American Heart Association, 2020, PMID: 32319345
Pitoulis FG, Hasan W, Papadaki M, Clavere NG, Perbellini F, Harding SE, Kirk JA, Boateng SY, de Tombe PP, Terracciano CM. Intact myocardial preparations reveal intrinsic transmural heterogeneity in cardiac mechanics. Journal of Molecular and Cellular Cardiology, 2020, PMID: 32201175
2019
Kirk JA, de Boer R. Moving -3 Galectin Closer to the Goal Line. American Journal of Physiology Heart and Circulatory Physiology, Dec 21, 2018. PMID: 30575435
2018
Rattanasopa C*, Kirk JA*, Bupha-Intr T, Papadaki M, de Tombe P, Wattanapermpool J. Estrogen but not testosterone preserves function from doxorubicin-inducedcardiotoxicity by reducing oxidative modifications. American Journal of Physiology Heart and Circulatory Physiology, 2018 Nov 30, PMID: 30499711
Papadaki M*, Holewinski RJ*, Previs S, Martin T, Stachowski MJ, Blair C, Van Eyk JE, Campbell KS, Warshaw DM, Kirk JA. Methylglyoxal inducedmodifications of myofilament proteins reduce function. JCI Insight, 2018;3(20):e121264, PMID: 30333300, PMCID: PMC6237482
Stachowski M, Holewinski RJ, Grote, E, Van Eyk JE, Kirk JA. Phospho-proteomics in Dyssynchrony and Resynchronization reveal signaling networks. Proteomics, 2018. PMID: 30129105
Kirk JA, Frangogiannis NG. Galectin-3 in the pathogenesis of heart failure: a causative mediator or simply a biomarker? AJP: Heart and Circ Phys, 2018, PMID: 2949
2017
Hsu S, Kokkonen KM, Kirk JA, Kolb TM, Damico RL, Mathai SC, Mukherjee M, Shah AA, Wigley FM, Rosen LC, Margulies KB, Hassoun PM, Halushka MK, Tedford RJ, Kass DA. Opposite Right Ventricular Myofilament Functional Changes in Human with Systemic Sclerosis-associated versus Idiopathic Pulmonary Arterial Hypertension. Circulation, 2018, PMID: 29352073
Ranek MJ, Stachowski MJ, Kirk JA, Willis MS. The role of heat shock proteins and co-chaperones in heart failure. Philosophical Transaction B, 2017, DOI: 10.1098/rstb2016.0530
Sonaglioni A, Baravelli M, Lombardo M, Sommese C, Anza C, Kirk JA, Padeletti L. Ventricular-arterial coupling in centenarians without cardiovascular disease. Aging Clin Exp Res, 2017, doi:10/1007/s50520-017-0783-y, PMID: 28616854
2016
Ngkelo A, Richart, A, Kirk JA, Bonnin P, Vilar J, Lemitre M, Marck P, Le Gall S, Renault N, Rank MJ, Kervadec A, Danelli L, Gautier G, Blank U, Launay P, Camerer E, Menashe P, Heumes C, Luche E, Casteilla L, Cousin B, Rodewald HR, Kass DA, Silvestre JS. Mast Cells Regulate myofilament calcium sensitization and heartfunction after myocardial infarction. Journal of Experimental Medicine, 2016; 213 (7), 1353-1374
Kirk JA, Holewinski RJ, Crowgey EL, Van Eyk JE. Protein Kinase G signaling in cardiac pathophysiology: Impactof Proteomics on clinical trials. Proteomics, 2016; 16 (5), 894-905, PMID: 26670943
Kirk JA, Cingolani OH. Thrombospondins in the Transition from Myocardial Infarction to Heart Failure. Journal of Molecular and Cellular Cardiology, 2016; 90: 102-110, doi:10.1016/j.yjmcc.2015.12.009
2015
Kirk JA*, Chakir K*, Lee KH*, Karst E, Holewinski RJ, Pironti G, Tunin RS, Pozios I, Abraham TP, de Tombe P, Rockman HA, Van Eyk JE, Craig R, Farazi TG, Kass DA. Pacemaker-InducedTransient Asynchrony Suppresses Heart Failure Progression. Science Translational Medicine, 2015; 7(319): 319ra207, PMID: 26702095
Kirk JA, Kass DA. Cellular andMolecular Aspects of Dyssynchrony and Resynchronization. Cardiac Electrophysiology Clinics, 2015; 7(4): 585-597, PMID: 26596804, PMCID: PMC4660268
Fert-Bober J, Giles JT, Holewinski RJ, Kirk JA, Uhrigshardt H, Crowgey EL, Andrade F, Bingham CO, Park JK, Halushka MK, Kass DA, Bathon JM, Van Eyk JE. Citrullination of myofilament proteins in heart failure. Cardiovasc Res, 2015; 108: 232-242, PMID: 26113265, PMCID: PMC4614685
Lee DI, Zhu G, Sasaki T, Cho G, Hamdani N, Holewinski R, Jo S, Danner T, Zhang M, Rainer PP, Bedja D, Kirk JA, Ranek MJ, Dostmann WR, Margulies, Van Eyk JE, Paulus WJ, Takimoto E, Kass, DA. Phosphodiesterase 9A controls nitric-oxide-independentcGMP and hypertrophic heart disease. Nature, 2015; 519: 472-476, PMID: 25799991, PMCID: PMC4376609
Selected Publications During Jonathan Kirk's Training
Kirk JA, Holewinski RJ, Kooij V, Agnetti G, Tunin RS, Witayavanitkul N, de Tombe PP, Gao WD, Van Eyk J, Kass DA. Cardiac Resynchronization Sensitizes the Sarcomere to Calcium by GSK-3β Re-Activation. Journal of Clinical Investigation, 2014; 124(1): 129-139, PMID: 24292707, PMCID: PMC3871225
Kirk JA, Saccomani MP, Shroff SG. A Priori Identifiability Analysis of Cardiovascular Models. Cardiovascular Engineering and Technology, 2013: 4(4): 500-512, PMCID: PMC4696755
Zhang P, Kirk JA, Ji W, dos Remedios CG, Kass DA, Van Eyk JE, Murphy AM. Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart. Circulation, 2012: 126: 1828-1837, PMID: 22972900, PMCID: PMC3733556.
Kirk JA, MacGowan GA, Evans C, Smith SH, Stewart AFR, Solaro RJ, Shroff SG. Left Ventricular and Myocardial Function In Mice Expressing Constitutively Psuedo-Phosphorylated Cardiac Troponin I. Circulation Research, 105(12): 1232- 1239, 2009, PMID: 19850940, PMCID: PMC28625552.
Martin TG*, Sherer LA*, Kirk JA. BAG3 localizes to mitochondria in cardiac fibroblasts and regulates mitophagy. American Journal of Physiology – Heart and Circulatory Physiology, 2024 (in press), * equal contributions
Ma W*, Lee KH*, Delligatti C*, Davis MT, Zheng Y, Gong H, Kirk JA, Craig R, Irving T. The structural and functional integrities of permeabilized porcine myocardium are mostly preserved by liquid nitrogen freezing. Journal of General Physiology, 2023, * co-first authors
Stachowski-Doll MJ, Papadaki M, Martin TG, Ma W, Gong HM, Shao S, Shen S, Muntu NA, Kumar M, Perez E, Martin JL, Moravec CS, Sadayappan S, Campbell SG, Irving T, Kirk JA. GSK-3β Localizes to the Cardiac Z-Disc to Maintain Length Dependent Activation. Circulation Research, 2022, PMID: 35168370
Martin TG, Kirk JA. Under construction: the dynamic assembly and degradation of the cardiac sarcomere. Journal of Molecular and Cellular Cardiology, 2020. PMID 32920010
Papadaki M*, Holewinski RJ*, Previs S, Martin T, Stachowski MJ, Blair C, Van Eyk JE, Campbell KS, Warshaw DM, Kirk JA. Methylglyoxal inducedmodifications of myofilament proteins reduce function. JCI Insight, 2018;3(20):e121264, PMID: 30333300, PMCID: PMC6237482
Kirk JA, Holewinski RJ, Crowgey EL, Van Eyk JE. Protein Kinase G signaling in cardiac pathophysiology: Impactof Proteomics on clinical trials. Proteomics, 2016; 16 (5), 894-905, PMID: 26670943
