Eaton DM*, Martin TG*, Kasa M, Djalinac N, Ljubojevic-Holzer S, Lewinksi D, Pottler M, Kampaengsri T, Krumphuber A, Scharer K, Maechler H, Zirlik A, McKinsey TA, Kirk JA, Houser SR, Rainer PP, Wallner M. HDAC inhibition regulates cardiac function by increasing myofilament calcium sensitivity and decreasing diastolic tension. Pharmaceutics, in press, 2022 *co-first authors

Stachowski-Doll MJ, Papadaki M, Martin TG, Ma W, Gong HM, Shao S, Shen S, Muntu NA, Kumar M, Perez E, Martin JL, Moravec CS, Sadayappan S, Campbell SG, Irving T, Kirk JA. GSK-3β Localizes to the Cardiac Z-Disc to Maintain Length Dependent Activation. Circulation Research, 2022, PMID: 35168370


Lindsey ML, Brunt KR, Kirk JA, Kleinbongard P, Calvert JW, de Castro Bras LE, DeLeon-Pennell KY, Del Re DP, Frangogiannis NG, Frantz S, Gumina RJ, Halade GV, Jones SP, Ritchie RH, Spinale FG, Thorp EB, Ripplinger CM, Kassiri Z. Guidelines for in vivo mouse models of myocardial infarction. American Journal of Physiology – Heart and Circulatory Physiology, 2021.

Lindsey ML, LeBlanc AJ, Ripplinger CM, Carter JR, Kirk JA, Keehan KH, Brunt KR, Kleinbongard P, Kassiri Z. Reinforcing rigor and reproducibility expectations for use of sex and gender in cardiovascular research. American Journal of Physiology – Heart and Circulatory Physiology, 2021.

Papadaki M, Kampaengsri T, Barrick SK, Campbell SG, Lewinski D, Rainer PP, Harris SP, Greenberg MG, Kirk JA. Myofilament glycation in diabetes depresses contractility by inhibiting tropomyosin movement, is rescued by cMyBPC domains. Journal of Molecular and Cellular Cardiology, 2021. PMID: 34487755

Martin TG, Delligatti CE, Muntu NA, Stachowski-Doll MJ, Kirk JA. Pharmacological inhibition of BAG3-HSP70 with the proposed cancer therapeutic JG-98 is toxic for cardiomyocytes. Journal of Cellular Biochemistry, 2021. PMID: 34487557

Kirk JA, Cheung CY, Feldman AM. Therapeutic targeting of BAG3: Considering its complexity in cancer and heart disease. Journal of Clinical Investigation. 2021. PMID: 34396980

Zhang M, Flury S, Kim CK, Chung WCJ, Kirk JA, Pak TR. Absolute quantification of phosphorylated ERβ amino acids in the hippocampus of women and in a rat model of menopause. Endocrinology. 2021. PMID: 34147032

Lindsey ML, de Castro Bras LE, DeLeon-Pennell KY, Frangogiannis NG, Halade GV, O’Meara CC, Spinale FG, Kassiri Z, Kirk JA, Kleinbongard P, Ripplinger CM, Brunt KR. Reperfused vs. Non-reperfused Myocardial Infarction: when to use which model. American Journal of Physiology – Heart and Circulatory Physiology, 2021. PMID: 34114891

Martin TG, Tawfik S, Moravec CS, Pak TR, Kirk JA. Cardiac Bcl-2-associated athanogene-3 (BAG3) expression and myofilament localization are differentially affected by age, sex, and disease. American Journal of Physiology – Heart and Circulatory Physiology, 2021. PMID: 33989081

Martin TG, Meyers VD, Dubey P, Dubey S, Perez E, Moravec CS, Willis MS, Feldman AM, Kirk JA. Cardiomyocyte Contractile Impairment in Heart Failure Results from Reduced BAG3-mediated Sarcomeric Protein Turnover. Nature Communications, 12(1): 2942, 2021. PMID: 34011988

Guo S, Okyere AD, McEachern E, Strong JL, Carter RL, Patwa VC, Thomas TP, Landy M, Song J, Lucchese AM, Martin TG, Gao E, Rajan S, Kirk JA, Koch WJ, Cheung JY, Tilley DG. Epidermal growth factor receptor-dependent maintenance of cardiac contractility. Cardiovascular Research, 2021. PMID: 33892492

Lindsey ML, Kassiri Z, Keehan KH, Brunt KR, Carter JR, Kirk JA, Kleinbongard, LeBlanc AJ, Ripplinger CM. We are the Change We Seek. American Journal of Physiology Heart and Circulatory Physiology, 2021


DiNello E, Bovo E, Thuo P, Martin TG, Kirk JA, Zima AV, Cao Q, Kuo IY. Deletion of cardiac polycystin 2/PC2 results in increased SR calcium release and blunted adrenergic reserve. American Journal of Physiology Heart and Circulatory Physiology, 2020. PMID: 32946258, PMCID: PMC7789970

Martin TG, Kirk JA. Under construction: the dynamic assembly and degradation of the cardiac sarcomere. Journal of Molecular and Cellular Cardiology, 2020. PMID 32920010

Ai L, Perez E, Heroux M, Zlobin A, Asimes AD, Hiske MA, Chung CS, Pak TR, Kirk JA. Adolescent Binge Alcohol Exposure Impairs Normal Heart Growth. Journal of the American Heart Association, 2020, PMID: 32319345

Pitoulis FG, Hasan W, Papadaki M, Clavere NG, Perbellini F, Harding SE, Kirk JA, Boateng SY, de Tombe PP, Terracciano CM. Intact myocardial preparations reveal intrinsic transmural heterogeneity in cardiac mechanics. Journal of Molecular and Cellular Cardiology, 2020, PMID: 32201175


Kirk JA, de Boer R. Moving -3 Galectin Closer to the Goal Line. American Journal of Physiology Heart and Circulatory Physiology, Dec 21, 2018. PMID: 30575435


Rattanasopa C*, Kirk JA*, Bupha-Intr T, Papadaki M, de Tombe P, Wattanapermpool J. Estrogen but not testosterone preserves function from doxorubicin-inducedcardiotoxicity by reducing oxidative modifications. American Journal of Physiology Heart and Circulatory Physiology, 2018 Nov 30, PMID: 30499711

Papadaki M*, Holewinski RJ*, Previs S, Martin T, Stachowski MJ, Blair C, Van Eyk JE, Campbell KS, Warshaw DM, Kirk JA. Methylglyoxal inducedmodifications of myofilament proteins reduce function. JCI Insight, 2018;3(20):e121264, PMID: 30333300, PMCID: PMC6237482

Stachowski M, Holewinski RJ, Grote, E, Van Eyk JE, Kirk JA. Phospho-proteomics in Dyssynchrony and Resynchronization reveal signaling networks. Proteomics, 2018. PMID: 30129105

Kirk JA, Frangogiannis NG. Galectin-3 in the pathogenesis of heart failure: a causative mediator or simply a biomarker? AJP: Heart and Circ Phys, 2018, PMID: 2949


Hsu S, Kokkonen KM, Kirk JA, Kolb TM, Damico RL, Mathai SC, Mukherjee M, Shah AA, Wigley FM, Rosen LC, Margulies KB, Hassoun PM, Halushka MK, Tedford RJ, Kass DA. Opposite Right Ventricular Myofilament Functional Changes in Human with Systemic Sclerosis-associated versus Idiopathic Pulmonary Arterial Hypertension. Circulation, 2018, PMID: 29352073

Ranek MJ, Stachowski MJ, Kirk JA, Willis MS. The role of heat shock proteins and co-chaperones in heart failure. Philosophical Transaction B, 2017, DOI: 10.1098/rstb2016.0530

Sonaglioni A, Baravelli M, Lombardo M, Sommese C, Anza C, Kirk JA, Padeletti 
L. Ventricular-arterial coupling in centenarians without cardiovascular disease. Aging Clin Exp Res, 2017, doi:10/1007/s50520-017-0783-y, PMID: 28616854


Ngkelo A, Richart, A, Kirk JA, Bonnin P, Vilar J, Lemitre M, Marck P, Le Gall S, Renault N, Rank MJ, Kervadec A, Danelli L, Gautier G, Blank U, Launay P, Camerer E, Menashe P, Heumes C, Luche E, Casteilla L, Cousin B, Rodewald HR, Kass DA, Silvestre JS. Mast Cells Regulate myofilament calcium sensitization and heartfunction after myocardial infarction. Journal of Experimental Medicine, 2016; 213 (7), 1353-1374

Kirk JA, Holewinski RJ, Crowgey EL, Van Eyk JE. Protein Kinase G signaling in cardiac pathophysiology: Impactof Proteomics on clinical trials. Proteomics, 2016; 16 (5), 894-905, PMID: 26670943

Kirk JA, Cingolani OH. Thrombospondins in the Transition from Myocardial Infarction to Heart Failure. Journal of Molecular and Cellular Cardiology, 2016; 90: 102-110, doi:10.1016/j.yjmcc.2015.12.009


Kirk JA*, Chakir K*, Lee KH*, Karst E, Holewinski RJ, Pironti G, Tunin RS, Pozios I, Abraham TP, de Tombe P, Rockman HA, Van Eyk JE, Craig R, Farazi TG, Kass DA. Pacemaker-InducedTransient Asynchrony Suppresses Heart Failure Progression. Science Translational Medicine, 2015; 7(319): 319ra207, PMID: 26702095

Kirk JA, Kass DA. Cellular andMolecular Aspects of Dyssynchrony and Resynchronization. Cardiac Electrophysiology Clinics, 2015; 7(4): 585-597, PMID: 26596804, PMCID: PMC4660268

Fert-Bober J, Giles JT, Holewinski RJ, Kirk JA, Uhrigshardt H, Crowgey EL, Andrade F, Bingham CO, Park JK, Halushka MK, Kass DA, Bathon JM, Van Eyk JE. Citrullination of myofilament proteins in heart failure. Cardiovasc Res, 2015; 108: 232-242, PMID: 26113265, PMCID: PMC4614685

Lee DI, Zhu G, Sasaki T, Cho G, Hamdani N, Holewinski R, Jo S, Danner T, Zhang M, Rainer PP, Bedja D, Kirk JA, Ranek MJ, Dostmann WR, Margulies, Van Eyk JE, Paulus WJ, Takimoto E, Kass, DA. Phosphodiesterase 9A controls nitric-oxide-independentcGMP and hypertrophic heart disease. Nature, 2015; 519: 472-476, PMID: 25799991, PMCID: PMC4376609

Previous Kirk Publications

Kirk JA, Paolocci N. New redox-related arrows in the arsenal of cardiac disease treatment. Antioxidant and Redox Signaling, 2014; 21(14): 1945-1948, PMID: 25211226

Kooij V*, Venkatraman V*, Kirk JA, Faber MJ, Ubaida-Mohien C, Graham DR, Van Eyk, JE. Identification of cardiac myofilament protein isoforms using multiple mass spectrometry based approaches. Proteomics – Clinical Applications, 2014; 8(7-8): 578 - 589, PMID: 24974818

Kooij V*, Venkatraman V*, Tra J, Kirk JA, Rowell J, Blice-Baum A, Cammarato A, Van Eyk JE. Sizing Up Models of Hear Failure: Proteomics from flies to humans. Proteomics - Clinical Applications. 2014, 8(10): 653-664, PMID: 24723306

Agnetti G, Halperin VL, Kirk JA, Chakir K, Guo Yurong, Lund L, Nicolini F, Gherli T, Guarnieri C, Caldarera CM, Tomaselli GF, Kass DA, Van Eyk JE. Desmin Modifications Associate with Amyloid Oligomers Deposition in Heart Failure. Cardiovascular Research, 2014; 102(1): 24-34, PMID: 24413773, PMCID: PMC3958618

Kirk JA, Holewinski RJ, Kooij V, Agnetti G, Tunin RS, Witayavanitkul N, de Tombe PP, Gao WD, Van Eyk J, Kass DA. Cardiac Resynchronization Sensitizes the Sarcomere to Calcium by GSK-3β Re-Activation. Journal of Clinical Investigation, 2014; 124(1): 129-139, PMID: 24292707, PMCID: PMC3871225

Kirk JA, Kass DA. Electromechanical Dyssynchrony and Resynchronization of the Failing Heart. Circulation Research, 2013, Aug 30; 113(6): 765-76, PMID: 23989718, PMCID: PMC3874431

Kirk JA, Saccomani MP, Shroff SG. A Priori Identifiability Analysis of Cardiovascular Models. Cardiovascular Engineering and Technology, 2013: 4(4): 500-512, PMCID: PMC4696755

Kirk JA*, Zhang P*, Murphy AM, Van Eyk JE. Troponin I alterations detected by multiple-reaction monitoring: How might this impact the study of heart failure? Expert Reviews in Proteomics, 2013: 10(1): 5-8, PMID: 23414352, *equal contributions

Shroff SG, Kirk JA. Troponin I Phosphorylation and Cardiac Contraction: Insights Provided by Mathematical Model-Based Analysis of Data. 2013 IEEE Engineering in Medicine & Biology Short Papers, No 1462

Zhang P, Kirk JA, Ji W, dos Remedios CG, Kass DA, Van Eyk JE, Murphy AM. Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart. Circulation, 2012: 126: 1828-1837, PMID: 22972900, PMCID: PMC3733556.

Rainer PP, Doleschal B, Kirk JA, Sivakumaran V, Maechler H, Hoefler G, Bauernhofer T, Samonigg H, Hutterer G, Kass DA, Pieske B, von Lewinski D, Pichler M. Sunitinib causes dose-dependent negative functional effects on myocardium and cardiomyocytes. British Journal of Urology International, 2012, Nov; 110(10): 1455-62, PMID: 22508007

Gupta A, Akki A, Wang Y, Leppo M, Chacko V, Foster DB, Caceres V, Shi S, Kirk JA, Su J, Lai S, Paolocci N, Steenbergen C, Gerstenblith G, Weiss RG. Creatine Kinase-Overexpression Improves Function in Murine Heart Failure, Causal Evidence the Failing Heart is Energy-Starved. Journal of Clinical Investigation, 2012; 122(1): 291–302, PMID: 22201686, PMCID: PMC3248286.

Cingolani OH, Kirk JA, Seo K, Koitabashi N, Lee DI, Ramirez-Correa G, Bedja D, Barth AS, Moens AL, Kass DA. Thrombospondin-4 is Required for Stretch-mediated Contractility Augmentation in Cardiac Muscle. Circulation Research, 2011 Dec 9;109(12):1410-4, PMID: 22034490, PMCID: PMC3324097.

Clause KC, Tinney JP, Liu LJ, Gharaibeh B, Huard J, Kirk JA, Shroff SG, Fujimoto KL, Wagner WR, Ralphe JC, Keller BB, Tobita K. A three-dimensional gel bioreactor for assessment of cardiomyocyte induction in skeletal muscle derived stem cells. Tissue Eng Part C Methods, 16(3): 375-385, 2010, PMID: 19601695, PMCID: PMC2945363

Kirk JA, MacGowan GA, Evans C, Smith SH, Stewart AFR, Solaro RJ, Shroff SG. Left Ventricular and Myocardial Function In Mice Expressing Constitutively Psuedo-Phosphorylated Cardiac Troponin I. Circulation Research, 105(12): 1232- 1239, 2009, PMID: 19850940, PMCID: PMC28625552. 

Naghshin J, McGaffin K, Mathier MA, Romano LC, Smith SH, Janczewski AM, Kirk JA, Shroff SG, O’Donnell CP. Chronic Intermittent Hypoxia Increases Left Ventricular Contractility in C57BL/6J Mice. J Appl Physiol, 107: 787-793, 2009, PMID: 19589954, PMCID: PMC2756000

MacGowan GA, Kirk JA, Evans C, Shroff SG. Pressure-Calcium relationships in perfused mouse hearts. Am J Physiol Heart Circ Physiol 290: 2614-2624, 2006, PMID: 16415077. 
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